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While the exact biochemical mechanisms through which polyphenolic compounds protect skeletal muscle cells are not fully understood (48), their protective actions may occur at the intracellular level, through direct or indirect interactions with transcription factors such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), Nuclear Respiratory Factor 1 (Nrf1), mitochondrial transcription factor A (TFAM), or myogenic regulators such as myogenin, Myogenic Factor 5 (Myf5), and Myoblast Determination Protein 1 (MyoD) (49)